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Funai Lab

Publications

Selected Publications

  1. Eshima H, Shahtout JL, Siripoksup P, Pearson MJ, Mahmassani ZS, Ferrara PJ, Lyons AW, Maschek JA, Peterlin AD, Verkerke ARP, Johnson JM, Salcedo A, Petrocelli JJ, Miranda ER, Anderson EJ, Boudina S, Ran Q, Cox JE, Drummond MJ, Funai K. Lipid hydroperoxides promote sarcopenia through carbonyl stress. eLife. 12:e85289, 2023. https://elifesciences.org/articles/85289
  2. Ferrara PJ, Lang MJ, Johnson JM, Watanabe S, McLaughlin KL, Maschek JA, Verkerke ARP, Siripoksup P, Chaix A, Cox JE, Fisher-Wellman KH, Funai K. Weight loss improves skeletal muscle mitochondrial energy efficiency. Life Metabolism. In Press.
  3. Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K. Mitochondrial phosphatidylethanolamine directly regulates UCP1 to promote brown adipose thermogenesis. Science Advances. 9(8):eade7864, 2023. PubMed Central PMCID: PMC9956115
  4. Miranda ER, Shahtout JL, Funai K. Chicken or Egg? Mitochondrial phospholipids and oxidative stress in disuse-induced skeletal muscle atrophy. Antioxidants & Redox Signaling. 38(4-6):338-351, 2023.PubMed Central PMCID: PMC9986029.
  5. Miranda ER, Funai K. Suppression of de novo sphingolipid biosynthesis mitigates sarcopenia. Nature Aging. 2, 1088-1089, 2022.PubMed Central PMCID: PMC7426366
  6. Ferrara PJ, Verkerke ARP, Maschek JA, Shahtout JL, Siripoksup P, Eshima H, Johnson JM, Petrocelli JJ, Mahmassani ZS, Green TD, McClung JM, Cox JE, Drummond MJ, Funai K. Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding. FASEB J. 2021 Oct;35(10):e21867. PubMed Central PMCID: PMC8439548.
  7. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. J Clin Invest. 2021 Apr 15;131(8).PubMed Central PMCID: PMC8262507.
  8. Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K. Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. J Appl Physiol (1985). 2020 Jul 1;129(1):124-132. doi: 10.1152/japplphysiol.00456.2019. Epub 2020 Jun 18. PubMed PMID: 32552434; PubMed Central PMCID: PMC7469234.
  9. Funai K, Summers SA, Rutter J. Reign in the membrane: How common lipids govern mitochondrial function. Curr Opin Cell Biol. 2020 Apr;63:162-173. Epub 2020 Feb 24. Review. PubMed PMID: 32106003; PubMed Central PMCID: PMC7484982.
  10. Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K. Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Mol Metab. 2020 Jan;31:55-66. Epub 2019 Nov 8. PubMed PMID: 31918922; PubMed Central PMCID: PMC6889607.
  11. Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai K. Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. Nat Metab. 2019 Sep;1(9):876-885. Epub 2019 Sep 16. PubMed PMID: 32405618; PubMed Central PMCID: PMC7218817.
  12. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv. 2019 Sep;5(9):eaax8352. eCollection 2019 Sep. PubMed PMID: 31535029; PubMed Central PMCID: PMC6739096.
  13. Ferrara PJ, Verkerke ARP, Brault JJ, Funai K. Hypothermia Decreases O2 Cost for Ex Vivo Contraction in Mouse Skeletal Muscle. Med Sci Sports Exerc. 2018 Oct;50(10):2015-2023. doi: 10.1249/MSS.0000000000001673. PubMed PMID: 29787474; PubMed Central PMCID: PMC6138518.
  14. Johnson JM, Ferrara PJ, Verkerke ARP, Coleman CB, Wentzler EJ, Neufer PD, Kew KA, de Castro Brás LE, Funai K. Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome. J Mol Cell Cardiol. 2018 Aug;121:94-102. Epub 2018 Jul 2. PubMed PMID: 30008435; PubMed Central PMCID: PMC6178222.
  15. Heden TD, Ryan TE, Ferrara PJ, Hickner RC, Brophy PM, Neufer PD, McClung JM, Funai K. Greater Oxidative Capacity in Primary Myotubes from Endurance-trained Women. Med Sci Sports Exerc. 2017 Nov;49(11):2151-2157. PubMed PMID: 28617704; PubMed Central PMCID: PMC5645226.
  16. Heden TD, Neufer PD, Funai K. Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria. Trends Endocrinol Metab. 2016 Aug;27(8):553-562. Epub 2016 Jun 28. Review. PubMed PMID: 27370525; PubMed Central PMCID: PMC4958499.
  17. Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Diabetes. 2016 Feb;65(2):358-70. Epub 2015 Oct 28. PubMed PMID: 26512026; PubMed Central PMCID: PMC4747455.
  18. Paran CW, Zou K, Ferrara PJ, Song H, Turk J, Funai K. Lipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy. Biochim Biophys Acta. 2015 Dec;1851(12):1530-8. Epub 2015 Sep 8. PubMed PMID: 26361872; PubMed Central PMCID: PMC4619134.
  19. Paran CW, Verkerke AR, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Obesity (Silver Spring). 2015 Jul;23(7):1440-9. Epub 2015 May 13. PubMed PMID: 25970801; PubMed Central PMCID: PMC4483165.